A recent study reveals that CD36 + CAFs internalize Ox-LDL to trigger lipid peroxidation, subsequently secreting macrophage migration inhibitory factor (MIF) to recruit MDSCs, thereby establishing an immunosuppressive TME (Zhu 2023).In recurrent glioblastoma, NOX4-mediated endothelial ferroptosis is upregulated, yet its underlying mechanisms require further investigation (Liang et al. 2024). This evidence concerns the gene MIF and glioblastoma.