Gene rearrangements of EWSR1 or FUS have also been shown to drive other sarcomas, including neuroectodermal tumor (ZNF278 and POU5F1), myxoid liposarcoma (DDIT3), clear cell sarcoma (ATF1 and CREB1), desmoplastic small round cell sarcoma (WT1), extra skeletal myxoid chondrosarcoma (NR4A3), hidradenoma (POU5F1 and PBX1), mucoepidermoid carcinoma (POU5F1), and leukemias (ZNF384) (Grunewald et al., 2018; Riggi et al., 2007, 2021). The gene discussed is POU5F1; the disease is primitive neuroectodermal tumor.