This study screens out the molecule TMCO3 with high N6‐methyladenosine (m6A) modification level in tumor samples compared to the adjacent non‐cancerous tissues of three pairs of HCC patients through Methylated RNA Immunoprecipitation Sequencing (MeRIP‐seq) and RNA sequencing (RNA‐seq). Here, SLC9D1 is linked to hepatocellular carcinoma.