METTL3 and hepatocellular carcinoma: In recent years, studies on m6A modification in tumors have been emerging, with a growing number of reports focusing on its role in HCC.[21] Classic m6A modifications are primarily conducted by “writers” such as METTL3/METTL14/WTAP or “erasers” like ALKBH5/FTO, modifying the m6A sites on targeted gene mRNA; “readers” such as IGF2BP1/2/3, YTHDF1/2/3 recognize and bind to the target gene mRNA for stabilization or degradation.[22] Our study discovered for the first time that ALKBH5 downregulated the m6A methylation level of TMCO3 mRNA, with IGF2BP2 participating in its mRNA stabilization.