The oncogenic role of TMCO3 in HCC has been previously reported, but the specific mechanisms are still unclear.[10] The further to explore the mechanism through which TMCO3 promotes the progression of HCC, immunoprecipitation (IP) followed by MS was performed to identify potential TMCO3 interaction proteins, AKT appeared at the top of the ranking (Figure4A,B; Table S4, Supporting Information). Here, AKT1 is linked to hepatocellular carcinoma.