Indeed, GD3 is strongly engaged by Siglec‐7 on NK cells, leading to immunosuppressive responses in vitro and in vivo.[37] Furthermore, dehydroxylated ceramide‐containing GD3 reduced the sensitivity to NK cells, indicating that modifications in ceramide‐containing glycosphingolipids not only influence Siglec‐7 binding properties but also impact the biological effects triggered by their interactions.[38] Notably, cancers typically show significantly lower levels of FA2H (fatty acid 2‐hydroxylase) than corresponding normal tissues, such as skin and colon. The gene discussed is SIGLEC7; the disease is cancer.