After myocardial infarction, a controlled inflammatory response is essential for clearing necrotic tissue and cellular debris from the infarcted area.[32] This response requires the coordinated action of multiple cell types and organs.[33] Our research demonstrates that MCPIP1 plays a central role in regulating this process by modulating macrophage polarization, fibroblast activation, and splenic immune cell output. Here, ZC3H12A is linked to myocardial infarction.