Additionally, upregulation of Delta‐like ligand 3 (DLL3) mRNA in Exo and its membrane protein (mProtein) in extracellular vesicles associated with tumor (tEV) may distinguish both limited‐ and extensive‐stage SCLC patients from high‐risk smokers, with AUC/ROC values of 0.836 and 0.839, respectively. The gene discussed is DLL3; the disease is small cell lung carcinoma.