The highest AUC/ROC was observed when ASCL1 and POU2F3 Exo‐mRNA expressions were combined with the dual DLL3 Exo‐mRNA/tEV‐mProtein expression for a biomarker classifier: 0.912 for LS‐SCLC patients and 0.963 for ES‐SCLC patients (Figure 5F,G). This evidence concerns the gene DLL3 and small cell lung carcinoma.