In mitochondria, PHB1 is located in the inner membrane and regulates mitochondrial fusion and fission by stabilizing optic atrophy protein 1 (OPA1) and dynamin‐related protein 1 (DRP1).[22] Moreover, PHB1 regulates OXPHOS activity and promotes mitochondrial respiration by modulating the stability of OXPHOS complexes.[23, 24] Nevertheless, the molecular regulation of PHB1 in CRC is not yet fully understood. This evidence concerns the gene PHB1 and colorectal carcinoma.