ARIH1 has been found to be highly expressed in various cancer cells, particularly in breast cancer and lung adenocarcinoma.[14] ARIH1‐mediated mitophagy and ARIH1‐induced translational arrest, which are mediated by 4E‐homologous protein (4EHP), contribute to therapeutic resistance in cancer cells.[14, 15] Our study reported that ARIH1 can promote the proliferation and metastasis of CRC cells by ubiquitinating the downstream protein PHB1, suggesting that ARIH1 may function as a promoting factor in cancer progression. This evidence concerns the gene PHB1 and cancer.