In diseases such as cancer, sepsis, and aging, fast glycolytic fibers (type II) are particularly susceptible to atrophy, whereas slow oxidative fibers (type I) are more resistant.[41, 42] Our study revealed that lncRNA‐MEG3 preferentially induces atrophy in glycolytic muscle fibers and promotes a transition towards slow myosin heavy chain (MHC) isoforms. The gene discussed is MEG3; the disease is Sepsis.