CD8A and neoplasm: This process facilitates the maturation of dendritic cells (DCs), leading to the activation of CD8+ T cells and the conversion of the immunosuppressive “cold tumor” into an immunologically active “hot tumor.” MPPC@CM alleviates hypoxia and enhances beam energy deposition for radiosensitization while also functioning as a GSH scavenger and disruptor of ROS homeostasis to induce ferroptosis.