Searching for brain‐derived molecules with the capacity to induce cytotoxicity of brain‐metastasizing melanoma cells (BMMC), we discovered that an α/β hemoglobin dimer induces apoptosis/necrosis of BMMC and downregulates three proteins: BRD4, GAB2, and IRS2, which are crucial components of cell viability and sustainability.43, 44, 45. The gene discussed is IRS2; the disease is melanoma.