Collybistin is responsible for delivering gephyrin to inhibitory synapses, and artificial or X‐linked intellectual disability/epilepsy mutations affecting the SH3 or PH domains cause mis‐localization of gephyrin and inhibitory receptors (Kins et al. 2000; Harvey, Duguid et al. 2004; Kalscheuer et al. 2009; Reddy‐Alla et al. 2010; Chiou et al. 2019). This evidence concerns the gene GPHN and epilepsy.