While the Combitype‐2 had moderate viral RNA load along with intermediate levels of inflammatory and endothelial dysfunction biomarkers, the Combitype‐3 showed the highest concentration in plasma of lipocalin‐2, MPO, VCAM‐1, PTX‐3, IL‐10, CXCL10, angiopoietin‐2, IL‐6, IL‐15, endothelin‐1, IL‐8, and TREM‐1, indicating an exacerbated pro‐inflammatory profile coupled with higher endothelial dysregulation and very high viral RNA load in plasma. The gene discussed is VCAM1; the disease is endothelial dysfunction.