The western blot results verified a significant decrease in the level of CRTC1 (p < 0.05) and p‐AMPK (p < 0.05) in both PFC (Figure 2B,D,F) and hippocampus (Figure 2C,E,G), suggesting that CRTC1 and AMPK may play critical roles in aging‐induced memory impairment in the NOR task. This evidence concerns the gene CRTC1 and memory impairment.