Using this strategy, we were not only able to blunt heart failure in HIV-1-infected Hu-mice and a rat model of Type 1 diabetic rats but also attenuated cardiac endothelial damage, increased the density of perfused microvessels, attenuated microvascular leakage and micro-ischemia, and decreased the expression of VAP-1 [33,68,144]. The gene discussed is AOC3; the disease is heart failure.