AOC3 and heart failure: We also showed that increasing the expression of Glo-I in HIV-1-infected Hu-mice using a custom-engineered adeno-associated virus designed to express Glo-I under inflammatory/oxidative conditions not only blunted heart failure, but it also attenuated cardiac endothelial damage, increased the density of perfused microvessels, attenuated microvascular leakage and micro-ischemia, and decreased the expression of VAP-1.