Moreover, for that, E5 is capable of suppressing the IFN I pathway by interacting with and binding to Mitochondrial Antiviral-Signaling Protein (MAVS) and Stimulator of IFN Genes (STING), with evidence of direct suppression of E5 on the activity of STING agonists in two mouse tumor challenge models [79]. Here, STING1 is linked to neoplasm.