Cyclooxygenase-2 (COX-2) is also widely reported as an enzyme capable of modulating the tumor microenvironment through its activation by the E5 oncoprotein, being responsible for producing type 2 prostaglandins (PGE2) that can bind to their specific receptors, producing a highly inflammatory tumor microenvironment [80]. The gene discussed is PTGS2; the disease is neoplasm.