A study conducted in patients with head and neck cancer demonstrated that high E5 expression correlates with the downregulation of multiple major histocompatibility complex (MHC) class I genes, including HLA-B, HLA-C, and HLA-F, as well as decreased expression of the Antigen Peptide Transporter 2 (TAP2), which is crucial for antigen processing [29]. The gene discussed is TAP2; the disease is head and neck cancer.