On the other hand, our study also revealed that caspase-3 and caspase-9 inhibitors, while alleviating apoptosis, paradoxically promoted necroptosis in IBV Conn A5968-infected cells, which is consistent with previous research showing that caspase inhibition can shift the balance toward necroptotic cell death in various viral infections [33]. The gene discussed is CASP9; the disease is viral infectious disease.