Notably, the enhanced necroptosis associated with IBV DMV/1639 infection was reversed by co-treatment with COX-2 inhibitors and PGE2 pathway modulators (exogenous PGE2 and BSP) (p > 0.05), whereas EP2 and EP4 receptor inhibition (TG4-155, L1-161) significantly exacerbated necroptosis (p < 0.05 and p < 0.0001, respectively, Figure 6D). Here, PTGS2 is linked to infection.