As a result, these potential biomarkers should be further assessed in relation to HBV-related complications such as HCC [30,31,32,33] We also highlighted HLA-A*01, HLA-B*08, HLA-B*38, HLA-C*01, HLA C*08, HLA-DRB1*03, and HLA-DQB1*05 alleles as potential markers for early detection or preventive measures for at-risk individuals since we found them in a statistically higher frequency in chronically infected patients vs. healthy people. The gene discussed is HLA-A; the disease is hepatocellular carcinoma.