CRP and Sepsis: Several biomarkers play an important role in sepsis diagnosis and prognosis: C-reactive protein (CRP) and procalcitonin (PCT) rise in response to systemic inflammation, lactate (LAC) indicates tissue hypoxia and metabolic distress, and D-dimers signal the activation of coagulation and fibrinolysis, often linked to disseminated intravascular coagulation in severe sepsis [6,7,8,9,10].