Therefore, the aim of this study was to investigate the association of the CTLA4 genetic variants rs5742909 (−318 C>T), rs231775 (+49 A>G), and rs3087243 (+6230 G>A) with HPV infection, the development of cervical intraepithelial lesions, and cervical cancer in a cohort of women from the southern region of Brazil. Here, CTLA4 is linked to cervical carcinoma.