In this study, we investigated associations between CT-measured canine lymphadenomegaly and elevated CRP in dogs without neoplastic disorders, targeting deep lymph nodes (cranial mediastinal, sternal, and internal iliac lymph nodes), based on our hypothesis that increased deep lymph node diameters would reflect increased levels of the acute-phase protein in conditions of systemic inflammation. The gene discussed is CRP; the disease is neoplastic disease or syndrome.