For instance, Martins et al. and Zhang et al. [13,19] reported that multiparous Holsteins with postpartum hypocalcemia had significantly higher concentrations of acute-phase proteins and proinflammatory cytokines, including serum amyloid A (SAA), haptoglobin, and tumor necrosis factor-α (TNF-α), associated with lower plasma calcium concentrations. The gene discussed is TNF; the disease is Hypocalcemia.