In this validation set, the early warning effectiveness of the three genes alone for DM–TB were AUC of 0.805 (CI: 0.725–0.885) for CETP, 0.833 (CI: 0.759–0.908) for TYROBP, and 0.892 (CI: 0.832–0.952) for SECTM1 (Figure 8D), with combined model warning ability increased to AUC = 0.901 (CI: 0.847–0.955) (Figure 8E). Here, SECTM1 is linked to tuberculosis.