The top 10 downregulated genes—LOC102724621, KRT7, COL1A1, FN1, TTBK1, XIST, ATP2B3, TSIX, LOC107987293, and CDC27P11—are associated with key biological processes such as extracellular matrix stability, cell adhesion, and signal transduction, and their downregulation may reflect altered tissue structure and impaired repair mechanisms in DM–TB pathology. The gene discussed is XIST; the disease is tuberculosis.