ADSL and infection: The key regulatory mechanisms through which AMPs modulate skin immunity and prevent infections include: (1) protection from microbial infection (broad spectrum of antimicrobial activity against bacteria, yeast, fungi, protozoa, and viruses); (2) improvement of skin barrier homeostasis (regulation of the normal skin microflora composition); (3) modulation of inflammation responses (controlling the production of various cytokines/chemokines), and (4) promotion of wound healing.