TPO and osteomyelitis: Mutation of msa in LAC contributes to the pathogenesis of implant-associated osteomyelitis and potentially important phenotypes including persister cell formation, cell wall formation, autolysis, and capsule production, and while there is phenotypic overlap with sarA mutants the extent to which this can be attributed to the impact of msa on sarA expression is unclear [163,164,165,166].