In multiple sclerosis (MS), rAAV vectors encoding myelin oligodendrocyte glycoprotein (MOG) induce antigen-specific Foxp3+ T-cell expansion in the liver, bypassing MHC restrictions to alleviate experimental autoimmune encephalomyelitis (EAE), a key MS mode [16,17]. The gene discussed is FOXP3; the disease is myeloid sarcoma.