In addition to the strong association of Dectin-1 and Dectin-2 with fungal immunity, studies have shown that Dectin-3-deficient mice are more susceptible to the induction of DSS-induced colitis and are defective in promoting tissue repair in colonic epithelial cells, possibly related to defective NF-κB activation and reduced IL-6 production [55]. The gene discussed is CLEC7A; the disease is colitis.