Probiotics containing Lactobacillus fermentum MCC2759 and MCC2760 showed a similar tendency to upregulate the gene expression of IL-10 and downregulate the gene expression of pro-inflammatory molecules, such as TNF-α, IL-6, and IL-1β in an animal model of diabetes induced by the feeding of a personalized diet and administration of streptozotocin [34]. This evidence concerns the gene IL1B and diabetes mellitus.