Moreover, SB probiotics administration in leptin-resistant obese and type 2 diabetic mice (db/db) was associated with reduced body weight and accumulation of fatty tissue, decreased liver steatosis, and hepatic and systemic concentration of inflammatory cytokines; colonic local effects were observed after SB treatment regarding the amelioration of the cecum morphological structure and gut microbiota composition [25]. The gene discussed is LEP; the disease is type 2 diabetes mellitus.