We present the case of a 55-year-old male who received an allogeneic hematopoietic stem cell transplant (HSCT) from an HLA-matched sibling donor for acute myeloid leukemia/myelodysplastic syndrome (AML/MDS) with TP53 mutation, seven years after a lung transplant. This evidence concerns the gene TP53 and acute myeloid leukemia.