NOTCH2 and melanoma: For instance, DLL3/Notch 2 are involved in the regulation of proliferation and invasion of pituitary adenomas [38], DLL3/Notch 2/Notch 4 in the survival and growth of melanoma cells [39], and DLL3/Notch 2/Notch 3 in the proliferation and differentiation of ovarian cancer cells, being associated with poor survival [40].