The enhanced oral bioavailability of PTX, as shown by augmented AUC and maximum concentration (Cmax) in experimental Sprague Dawley rats, along with TPGS-mediated P-gp efflux inhibition, contributes to an improved anti-tumor effect in a H22 liver tumor xenograft and a A549 lung tumor xenograft mice model. Here, PGP is linked to neoplasm.