Cai et al. demonstrated that intravenously injected Momordica charantia-derived exosome-like nanoparticles (ELNs) delivered miR-5266, downregulating MMP-9, improving the BBB function, reducing infarction area, and mitigating neurological damage in a rat middle cerebral artery occlusion model [180]. This evidence concerns the gene MMP9 and medical procedure.