This mechanism is particularly interesting for several reasons: (I) the role of miR-103-3p in carcinogenesis has been described in various tumors [564,565]; (II) in NSCLC, the miR-103-3p/PTEN interaction regulates AKT-inducing cell proliferation and invasion [566]; (III) miR-103-3p sponging by lncRNAs is involved in the regulation of different hallmarks of cancer [567,568]. This evidence concerns the gene PTEN and cancer.