For example, several mtDNA mutations are correlated with HCC progression, namely G3842A, which creates a premature stop codon in the mtND1 gene; A11708G, which results in amino acid substitutions in the mtND4 gene; and 12418insA, which result in frame shift mutations in the mtND5 gene [97]. This evidence concerns the gene MT-ND5 and hepatocellular carcinoma.