BAX and cancer: Moreover, saponins and triterpenes stimulate apoptosis of cancer cells through the upregulation of caspase-3 and downregulation of Bax (proapoptotic protein) and Bcl-2 (antiapoptotic protein) secretion, leading to the disintegration of poly (ADP-ribose) polymerase accompanied by DNA fragmentation and condensation of nuclear chromatin [104,105].