Studies have also shown that mutated TDP-43 (p.Q331K and p.M337V mutations) might impact mitochondrial dynamics (fusion and fission) and function by colocalizing with mitochondria in axon and skeletal muscle fibers and impairing mitochondrial complex levels, mitochondrial membrane potential, mitochondrial length and density, and their transport in axons in ALS disease conditions [31,32]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.