TARDBP and axonal neuropathy: Several ALS-linked mutations, including p.M337V in the TDP-43 gene, have been shown to trigger the overexpression of the insoluble form of TDP-43 in neurons, causing cytoplasmic aggregation, dysfunctional mitochondrial and cellular proteostasis systems, axonal neuropathy, abnormal neurites, and decreased cell viability [26,27].