TGFB1 and Hepatic fibrosis: Furthermore, Nanthirudjanar et al. showed that HYA reduces lipid accumulation in hepatocytes [19], and we have recently reported that HYA ameliorates liver fibrosis in a mouse model of metabolic dysfunction-associated steatohepatitis (MASH) by inhibiting the TGF-β pathway in hepatic stellate cells [20].