CUR supplementation significantly reduced circulating levels of key peptides for insulin resistance that are strongly engaged in inflammation and apoptosis, glycogen synthase kinase-3 β (GSK-3β) (−2.4 ± 0.4 ng/mL vs. −0.3 ± 0.6, p = 0.0068) and islet amyloid polypeptide (IAPP) (−2.0 ± 0.7 ng/mL vs. 0.4 ± 0.6, p = 0.0163) levels, compared with the placebo group. The gene discussed is IAPP; the disease is Insulin resistance.