AHR and colorectal carcinoma: Similarly, we detected an increase in Akkermansia (phylum Verrucomicrobia, family Verrucomicrobiaceae), specifically Akkermansia muciniphila, which has been shown to protect against CRC development in murine models by inhibiting the AhR/β-catenin signaling pathway [75], in addition to promoting the release of extracellular vesicles that have a multitude of regulatory effects on health, including improved mucosal integrity, reduced intestinal permeability, and an increase in beneficial bacteria [76].