Nakano S et al. found an inverse relationship between vitamin D intake and CRC risk in the presence of high VDR expression in stroma (highest third vs. lowest third: HR 0.46 [0.23–0.94]; p-trend = 0.03), suggesting that high vitamin D intake (534.6 IU/day vs. 154.1 IU/day) may reduce colon cancer risk, but this is mainly dependent on stromal VDR expression [222]. The gene discussed is VDR; the disease is colonic neoplasm.