Piccinin et al. [26] recently demonstrated that the intestinal LXR may play a role in the hepatic cholesterol metabolism and SRB1 in a model of MASH-related HCC, suggesting that the specific activation of LXR axis in the gut may induce changes in the enteropathic circulation (e.g., enterokines and/or metabolites), thus modifying transcriptional regulation in distant organs, such as the liver. This evidence concerns the gene SCARB1 and hepatocellular carcinoma.