Specifically, wild-type p53 can restrict the growth of tumour cells by inhibiting glycolysis, promoting oxidative phosphorylation, and inhibiting the pentose phosphate pathway and fatty acid synthesis; in addition, p53 can regulate target genes such as TIGAR (glycolytic inhibitor) and GLS2 (glutaminase) and reduce reactive oxygen species (ROS) levels and inhibit anabolism [32,33]. Here, TIGAR is linked to neoplasm.