In conclusion, our studies are consistent with the following concepts: (1) diabetes risk prediction is useful in subjects with prediabetes, (2) a web-based personalized lifestyle program with professional review can be effective in reducing diabetes risk, and (3) the measurement of fasting glucose and insulin and the calculation of HOMAIR and HOMAβ are useful for identifying diabetic subjects with insulin deficiency and low production who may require insulin therapy. The gene discussed is INS; the disease is diabetes mellitus.