We found a significant interaction between Lp(a) and hs-CRP (Pinteraction log Lp(a) × log hs-CRP < 0.001 and Pinteraction Lp(a) (<50 or ≥50 mg/dL) × hs-CRP (<2 or ≥2 mg/L) < 0.001) and investigated the impact of hs-CRP levels on Lp(a)-associated ASCVD risk by stratifying subjects according to hs-CRP categories (“normal hs-CRP” < 2 mg/L vs. “high hs-CRP” ≥ 2 mg/L) and Lp(a) categories (Lp(a) < 50 mg/dL vs. Lp(a) ≥ 50 mg/dL) (Figure 4). Here, LPA is linked to atherosclerosis.