Recently, an analysis from the Multi-Ethnic Study of Atherosclerosis (MESA) showed that elevated Lp(a) levels were associated with increased ASCVD risk only in those individuals with concomitant elevated hs-CRP levels (≥2 mg/L), suggesting that Lp(a)-associated ASCVD risk is exacerbated in a proinflammatory milieu [12]. This evidence concerns the gene CRP and atherosclerosis.