Moreover, in a study conducted on peripheral blood and colon tissues of 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced colitis rats, alongside a control group, it was observed that butyrate administration enhanced Treg cell functionality and decreased interleukin-17 (IL-17) levels, along with Th17 cells, in the TNBS-induced colitis rats, while the control group exhibited minimal changes in these parameters [66]. This evidence concerns the gene IL17A and colitis.