Although a relationship between certain epigenetic markers and the development of neurodegenerative diseases such as ALS has already been proposed, this study is the first to relate the D-loop, GSTP1, and the CpG1 site of LINE-1 with worse nutritional status in accordance with disease progression at diagnosis and mortality, with the D-loop being the best predictor for these outcomes. This evidence concerns the gene GSTP1 and neurodegenerative disease.