Interleukin 1-beta is one of the major proinflammatory cytokines [82], and its increased concentration is found in testes in a variety of systemic or local pathological processes, e.g., obesity [83], ischemia/reperfusion injury [84], or some drugs, such as methotrexate [85]. This evidence concerns the gene IL1B and obesity due to melanocortin 4 receptor deficiency.