We observed significantly lower numbers of CD68+ microglia cells in the hippocampal CA2 (p < 0.05), but not in areas CA1 and CA3 (Figure 8a, Figure 9A and Figure S3A), and in the lateral preoptic area (p < 0.05), and supraoptic nucleus (p < 0.001) (Table 1) in the STZIGF-1 group, compared with STZSAL rats 90 days after AD induction. Here, CD68 is linked to Alzheimer disease.