These potential targets, including EGFR, SRC, STAT3, HSP90AB1, AKT1, ESR1, PTGS2, MAPK1, ALB, TLR4, MMP9, CYP1A1, CYP19A1, AR, and NR3C1, were involved in the molecular mechanism of HCC pathogenesis. This evidence concerns the gene AKT1 and hepatocellular carcinoma.