These potential targets, including EGFR, SRC, STAT3, HSP90AB1, AKT1, ESR1, PTGS2, MAPK1, ALB, TLR4, MMP9, CYP1A1, CYP19A1, AR, and NR3C1, were involved in the molecular mechanism of HCC pathogenesis. Here, MAPK1 is linked to hepatocellular carcinoma.