These potential targets, including EGFR, SRC, STAT3, HSP90AB1, AKT1, ESR1, PTGS2, MAPK1, ALB, TLR4, MMP9, CYP1A1, CYP19A1, AR, and NR3C1, were involved in the molecular mechanism of HCC pathogenesis. The gene discussed is TLR4; the disease is hepatocellular carcinoma.