AKT1 and cancer: Notably, most of the key genes were enriched in the screened pathways, including hsa01100 metabolic pathways (38), hsa05200 pathways in cancer (35), hsa04151 PI3K-Akt signaling pathway (27), hsa05208 chemical carcinogenesis-reactive oxygen species (25), and hsa04010 MAPK signaling (25) as the top pathways.