AKT1 and neoplasm: Hwang-Bo et al. documented the inhibitory potential of 3-acetyloleanolic acid on tumor-induced angiogenesis and lymph-angiogenesis via suppression of angiopoietin-1/Tie-2 signaling and downstream signaling factors such as AKT, FAK, and ERK1/2 in CT-26 allograft colon carcinoma animal model [21].