ESR1 and hepatocellular carcinoma: Figure 7 shows the 44 nodes (9 bioactive compounds, 15 targets, and 20 pathways) and 141 edges in the network. The network revealed that most targets were influenced by at least one bioactive molecule, and all the hub genes were possibly involved in HCC-related targeted pathways. According to the degree analysis, MAPK1 (19), AKT1 (18), EGFR (18), SRC (13), STAT3 (10), MMP9 (9), PTGS2 (9), and ESR1 (9) showed the highest degree of association with multiple bioactives and pathways. This advocates the potential role in the mechanism of A. laxiflora bioactives against HCC.