The results found that ginsenoside Rb1 significantly reversed the endothelin-1 (ET-1)-induced upregulation of Twist1 (p < 0.05, p < 0.01 or p < 0.001), inhibited the downregulation of PGC-1α and PPARα (p < 0.05, p < 0.01 or p < 0.001), and alleviated cardiomyocyte injury and energy metabolism disorders (Figure 7). Here, PPARGC1A is linked to Disorder of energy metabolism.