Du Lixin et al. demonstrated that ginsenoside Rb1- PLGA nanoparticles significantly improved myocardial oxidative stress damage and pathological conditions in HF rats by activating the reactive oxygen species (ROS)/peroxisome proliferator-activated receptor alpha (PPARα)/peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) pathway [11]. This evidence concerns the gene PPARGC1A and hydrops fetalis.