Therefore, we regard Twist1 as the starting point, combined with its regulatory effects on PGC-1α and PPARα, to verify the regulatory role of ginsenoside Rb1 in heart fibrosis caused by energy metabolism imbalance in HF through interfering with Twist1, with a view to providing potential sources for new diagnostic and prognostic biomarkers of energy metabolism disorder in HF. The gene discussed is PPARA; the disease is hydrops fetalis.