Superoxide dismutase (SOD), a key regulator of oxidative stress, was markedly reduced in the AOM-only group (G2) to 2.30 U (95% CI: 2.05–2.54) compared to 6.46 U (95% CI: 5.84–7.09) in the control group (G1). Here, SOD1 is linked to infectious otitis media.