For instance, miR-200c downregulated in NSCLC can restore sensitization to gefitinib in the resistant cell line PC-9-ZD through targeting ZEB1 (zinc finger E-box-binding homeobox 1), and then, by inhibiting the PI3K/Akt signaling pathway and inducing apoptosis [85]. This evidence concerns the gene ZEB1 and non-small cell lung carcinoma.