NANOG and cancer: It also decreases the migration capacity and pluripotency of the cells by reducing the expression levels of cancer stem cell (CSC) markers such as SOX2 (transcription factor SOX-2), NANOG (homeobox protein NANOG), ALDH1A1 (aldehyde dehydrogenase 1A1), POU5F1 (POU domain, class 5, transcription factor 1), KLF4 (Krueppel-like factor 4), and CD44.