For instance, miR-146b-5p promotes apoptosis of PE2988 and PE3479 NSCLC cells (isolated from malignant pleural effusions with exonic EGFR mutations and deletions) in the presence of osimertinib, favoring cleavage of caspase-3 and PARP by miR-146b-5p binding to IRAK mRNA. This evidence concerns the gene EGFR and non-small cell lung carcinoma.