In this regard, it has been described that a derivative of resveratrol—trans-3,5,4-trimethoxystilbene (TMS)—can effectively restore miR-345 and miR-498 expression and sensitize lung cancer cells to gefitinib (PC-9/gefitinib resistant) through MAPK1 and PIK3R1 (phosphatidylinositol 3-kinase regulatory subunit alpha) and ultimately regulate the MAPK/c-Fos and AKT/Bcl-2 (apoptosis regulator Bcl-2) signaling pathways [82]. Here, PIK3R1 is linked to lung carcinoma.